{"id":25407,"date":"2026-04-16T18:29:05","date_gmt":"2026-04-17T01:29:05","guid":{"rendered":"https:\/\/myotonic.org\/?p=25407"},"modified":"2026-04-16T18:29:05","modified_gmt":"2026-04-17T01:29:05","slug":"new-research-highlights-importance-of-heart","status":"publish","type":"post","link":"https:\/\/myotonic.org\/de\/new-research-highlights-importance-of-heart\/","title":{"rendered":"New Research Highlights Importance of Heart Health in DM"},"content":{"rendered":"<div class=\"col-xs-12 col-sm-6 col-md-12 col-lg-4 pull-right screen-placer\"><img decoding=\"async\" class=\"alignright\" src=\"https:\/\/myotonic.org\/wp-content\/uploads\/Cooper.jpg\" \/><\/div>\n<p><strong>Dr. Thomas Cooper at Baylor College of Medicine has recently published research revealing valuable new insights into myotonic dystrophy type 1 (DM1) and heart health.<br \/>\n<\/strong><br \/>\nThe findings, supported by the Myotonic Dystrophy Foundation, help answer questions about why the disease worsens over time and whether the damage can be reversed once the disease has begun. This work, conducted in an animal model of DM1, underscores the importance of early monitoring, early treatment and sex differences of cardiac symptoms in DM1.<\/p>\n<h3>Scientific Summary:<\/h3>\n<p>In a cardiac mouse model with conditional CUGexp overexpression, Dr. Cooper\u2019s team showed that suppressing CUGexp RNA reverses cardiac abnormalities, although this reversibility declines with prolonged expression. Results showed that cardiac conduction, contractility, and structural defects worsen over time, despite lacking evidence of progressive MBNL-related splicing disruption. These findings highlight the importance of early intervention to prevent severe cardiac complications, including arrhythmias, heart failure, and premature death.<\/p>\n<p><a href=\"https:\/\/blogs.bcm.edu\/2026\/04\/03\/from-the-labs-study-provides-answers-to-progressive-heart-problems-in-muscular-dystrophy-and-potential-reversibility\/\" target=\"_blank\" rel=\"noopener\">Click here to read the Baylor College of Medicine Press Release.<\/a><\/p>\n<p><a href=\"https:\/\/www.bcm.edu\/research\/faculty-labs\/tom-cooper-lab?PMID=14453\" target=\"_blank\" rel=\"noopener\">Click here to learn more about Dr. Cooper&#8217;s lab.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Thomas Cooper at Baylor College of Medicine has recently published research revealing valuable new insights into myotonic dystrophy type 1 (DM1) and heart health. The findings, supported by the Myotonic Dystrophy Foundation, help answer questions about why the disease worsens over time and whether the damage can be reversed once the disease has begun. [&hellip;]<\/p>\n","protected":false},"author":13,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70,72],"tags":[],"class_list":["post-25407","post","type-post","status-publish","format-standard","hentry","category-news","category-research"],"_links":{"self":[{"href":"https:\/\/myotonic.org\/de\/wp-json\/wp\/v2\/posts\/25407","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/myotonic.org\/de\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/myotonic.org\/de\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/myotonic.org\/de\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/myotonic.org\/de\/wp-json\/wp\/v2\/comments?post=25407"}],"version-history":[{"count":4,"href":"https:\/\/myotonic.org\/de\/wp-json\/wp\/v2\/posts\/25407\/revisions"}],"predecessor-version":[{"id":25457,"href":"https:\/\/myotonic.org\/de\/wp-json\/wp\/v2\/posts\/25407\/revisions\/25457"}],"wp:attachment":[{"href":"https:\/\/myotonic.org\/de\/wp-json\/wp\/v2\/media?parent=25407"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/myotonic.org\/de\/wp-json\/wp\/v2\/categories?post=25407"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/myotonic.org\/de\/wp-json\/wp\/v2\/tags?post=25407"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}