Myotonic dystrophy type 1 (DM1)
Myotonic dystrophy type 1 (DM1) is a genetic, progressive neuromuscular condition that affects muscles and multiple body systems. It can cause muscle weakness, myotonia, fatigue, and heart-related complications, with symptoms varying widely in severity and age of onset.
About myotonic dystrophy type 1 (DM1)
Myotonic dystrophy type 1 (DM1) is an inherited neuromuscular disorder that primarily affects muscle strength, function, and control. It is caused by a genetic mutation that leads to progressive muscle weakness and myotonia, which is the inability of muscles to relax after use. While DM1 most commonly impacts the muscles of the face, limbs, and respiratory system, it can also affect other areas such as the heart, digestive system, and endocrine function. Symptoms and severity vary widely from person to person, and they may appear at any age. As a multisystem condition, DM1 often requires coordinated care and long-term management to support mobility, independence, and overall quality of life.
Body systems affected
DM1 affects multiple body systems, some of which are listed below. Learn more on how myotonic dystrophy affects the body.
Central nervous system: Thinking, mood, sleep, and cognitive function.
Muscles: Muscles weakness, stiffness, and fatigue over time.
Respiratory system: Breathing, lunch function, and sleep-related respiratory challenges.
Cardiovascular system: Heart rhythm and conduction issues.
Videos about DM1 from the Digital Academy
Inheritance of myotonic dystrophy type 1 (DM1)
Published: February 21, 2025
How myotonic dystrophy type 1 (DM1) is inherited
Published: February 21, 2025
Use of human pluripotent stem cells for deciphering myotonic dystrophy type 1
Published: November 29, 2023
