Myotonic dystrophy type 2 (DM2)
Myotonic dystrophy type 2 (DM2) is an inherited neuromuscular disorder that primarily affects muscle strength, function, and control. It is caused by a genetic mutation in the CNBP gene that leads to progressive muscle weakness, stiffness, and pain.
About myotonic dystrophy type 2 (DM2)
Myotonic dystrophy type 2 (DM2) most commonly impacts the proximal muscles of the hips, thighs, and upper arms, but it can also affect other systems, including the heart, eyes, endocrine function, and metabolism. Symptoms and severity vary widely from person to person, and they usually appear in adulthood. As a multisystem condition, DM2 often requires coordinated care and long-term management to support mobility, independence, and overall quality of life.
Body systems affected
DM2 affects multiple body systems, some of which are listed below. Learn more on how myotonic dystrophy affects the body.
Muscles: Myotonia (difficulty relaxing muscles), proximal muscle weakness (hips, thighs, upper arms)
Respiratory system: Breathing, lung function, and sleep-related respiratory challenges.
Cardiovascular system: Heart rhythm and conduction issues.
Gastrointestinal system: Difficulty swallowing, acid reflux, heartburn, constipation or diarrhea, abdominal pain and bloating difficulties.
Endocrine system: Insulin resistance, thyroid dysfunction, and hormone issues.
Videos about DM2 from the Digital Academy
How myotonic dystrophy type 2 (DM2) is inherited
Published: September 24, 2025
DM2 Essentials: Understanding, Managing, and Thriving with DM2 - 2025 MDF Confer...
Published: August 28, 2025
Finding Relief: Exploring Medications & Tools for Managing Pain in DM2 - 202...
Published: August 28, 2025
DM2 resources
Where you can learn more
DM2 support group
Join the virtual DM2 support group on the 1st and 3rd Thursday of every month.
DM2 caregivers support group
For people caring for someone living with DM2 on the 3rd Tuesday of every month.
Educational resources
Explore educational materials designed to help you understand DM further.
